Multiple grayscale images can be combined as the channels of a single image. The images you want to merge must be in grayscale mode, be flattened (have no layers), have the same pixel dimensions, and be open. The number of grayscale images you have open determines the color modes available when merging channels. For example, if you have three images open, you can merge them into an RGB image; if you have four images open, they can become a CMYK image.